It’s one of those things that where if you need to ask. . .

However, let me try and tackle the OP’s question.  The answer is it depends.

Shotguns with pins are meant to be shot instinctively. They’re not meant to be deliberately aimed.  However, we do just that when we use them on turkeys.  I’ve hunted with one bead and two.  The system is really dependent on a good cheek weld, and that is not always possible with a gobbler.

Your hold is going to be determined at the patterning board.  Let’s say you have one bead. You put it at 6 O’Clock and touch one off.  It’s low.  So now you try dead-on and you get a good pattern.   In the end you may be 12 O’Clock at 40 yards and 6 O’Clock at 5.  You’ll have to practice.  2 Beads?  There is no set method, but normally you want to see no rib and have the back pin surrounded by the front pin.  That may change when you take it to the pattern board. The pins may line up as two concentric circles, or an 8 or the back pin may be shifted left or right.  It’s all about you, your cheek weld, the load, the distance, the choke and how you mount the shotgun. Unlike a scope, the pins require practice to figure out what is going to work.

Scopes take away a lot of that guesswork, but they’re also dependent on a consistent cheek weld.  One big benefit of a scope is that they give you feedback on your cheek weld.  You have to put your cheek right at the sweet spot in order to get the right sight picture.   Red Dots, reflex sights, and their like remove that requirement somewhat.  That is, they throw the dot on where the shotgun is aimed no matter what your cheek weld  at least up to a point.